科學研究：

研究方向：

主要從事間充質干細胞體內自我更新、分化以及衰老的調控機制；骨骼發育、骨代謝以及骨質疏松癥的發病機理；DNA損傷應激發應、衰老以及腫瘤發生的研究。

承擔科研項目情況：

1． 體內間充質干細胞自我更新、分化及其調控相關組織干細胞的機制研究，首席科學家。

2． Atm 介導的Smad1 磷酸化在DNA損傷應激反應及腫瘤發生中的作用，負責人。

3． 通過協調經典的Smad通路和非經典的MAPK通路調節BMP的功能以及成骨細胞分化，負責人。

科研成果：

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論文專著：

在Nature Genetics、Genes and Development、PNAS、Journal Cell Biology， Human Molecular Genetics， Cell等雜志發表40余篇學術文章。

出版專著：

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發表英文論文：

1.Gang Ma, Lili Li, Yuanyu Hu, Bijin Au, Lin He and Baojie Li* (2012). P53 represses Smad1 expression via p21-E2F pathway to control mesenchymal stem cell differentiation. J Mol Cell Biol, 4(2): 118-120.

2.Jenny Chau, Yuanyu Hu, Jianhe Wang, Zhi Liu, Bi Jin Au, Yuji Mishina, Ye-Guang Chen, Christine Biondi, Elizabeth Robertson, Yue-Zheng Du, Dong Xie, Xueying Wang, Qiang Yu, and Baojie Li* (2012). Integration of BMP signaling and Atm-p53 pathway at Smad1 in DNA damage response and oncogenesis. Nature Communications, In press.

3.Keng Po Lai, Wai Fook Leong, Jenny Fung Ling Chau, Deyong Jia, Li Zeng, Huijuan Liu, Aijun Hao, Lin He, Hongbing Zhang, David Meek, Chakradhar Velagapudi, Samy L. Habib, and Baojie Li* (2010). S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J., 29(17):2994-3006.

4. Leong W, Zhou T, Li B*. Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression. PLoS One. 2009; 4(1): e4135.

5. Wang X, Goh CH, Li B*. p38 MAPK regulate osteoblast differentiation through osterix. Endocrinology. 2007; 148(4):1629-1637.

6. Rasheed N, Wang X, Niu QT, Yeh J, Li B*. Atm deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoblastogenesis. Human Molecular Genetics. 2006; 15(12): 1938-1948.

7. Wang X, Kua HY, Hu Y, Guo K, Zeng Q, Wu Q, Ng HH, Karsenty G, de Crombrugghe B, Yeh J, Li B*. p53 represses the expression of transcription factor osterix and functions as a negative regulator of osteoblastogenesis and bone formation. J. Cell Biol. 2006; 172:115-125.

8. Hu Y，Wang X，Zeng L，Cai D，Sabapathy K，Goff SP，Firpo EJ and Li B* (2005). ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress. Mol. Biol. Cell. 16:3705-3718.

9. Li B*, Wang X, Rasheed N, Hu Y, Boast S, Ishii T, Nakayama K, Nakayama KI, Goff SP. Distinct roles for c-Abl and Atm in Prx I induction by modulating expression of protein kinase C. Genes and Development. 2004; 18:1824-1837.

10. Hu Y, Chan E, Wang X, and Li B* (2003) Activation of p38MAPK is required for osteoblast differentiation. Endocrinology 144(5):2068-2074.

11. Li B, Boast B, de los Santos K, Schieren I, Quiroz M, Teitelbaum SL, Tondravi MM, and Goff SP (2000). c-Abl knockout mice are osteoporotic and show defects in osteoblast maturation. Nature Genetics 24(3): 304-308.

發表中文論文：

1 博來霉素A_5和異博定聯合用藥對小鼠免疫功能的影響 李保界; 張鴻卿; 薛紹白; 高平; 王瑞海; 李嗣英 北京師范大學生物系; 中國醫學科學院醫藥生物學技術研究所 【期刊】北京師范大學學報(自然科學版) 1991-03-02

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榮譽獎勵：

1． 2009年入選上海“浦江人才”計劃。

2． 2001年獲美國HHMI和Cancer Research Institute博士后基金。

3． 獲美國骨礦研究協會“事業提升獎”(ASBMR: Career Enhancement Award， USA)。

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